Development of New Openers of ATP-Sensitive Potassium Channels of the Cell Membranes

1Strutynskyi, RB, 1Strutynska, NA, 1Maximyuk, OP, 2Platonov, MO, 3Boyko, OM, 2Vasylchenko, OV, 4Fedyanovich, IM, 1Dosenko, VYe., 1Krishtal, OO
1O.O. Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv
2Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv
3Taras Shevchenko National University of Kyiv
4Bogomoletz National Medical University, Dental Сenter, Kyiv
Nauka innov. 2016, 12(4):38-48
Section: Research and Engineering Innovative Projects of the National Academy of Sciences of Ukraine
Language: Ukrainian
Two innovative libraries (413 cyclosulfamides and 709 orthopyridine sulfamides) of potential new openers of ATP-sensitive potassium channels of cell membranes were developed. It is shown experimentally that at least ten new original compounds have properties of pharmacological openers of the channels. Seven compounds, namely Z851154982, Z56762024, Z1269122570, Z31153162, Z45679561, Z756371174 and Z649723638, open channels of both types — sarcoplasmic as well as mitochondrial membranes: Simultaneously, Z734043408 compound is a potent activator of aforementioned channels of sarcolemmal membrane only. Z31197374 and Z666664306 compounds show the affinity onlyto КATP-channels of mitochondrial type. The results of the work can be used by pharmaceutical companies and scientific research institutes.
Keywords: glibenclamide, KATP-channels, mitochondria, new openers, vasodilation effects