Long-Acting Composite Systems Based on Powdered Medicinal Plants and Nanosilica

1Turov, VV, 1Krupska, ТV, 1Golovan, AP, 1Andriyko, LS, 1Kartel, МТ
1Chuiko Institute of Surface Chemistry, NAS of Ukraine
Nauka innov. 2017, 13(2):59-67
Section: Research and Engineering Innovative Projects of the National Academy of Sciences of Ukraine
Language: Ukrainian
The state of water in the powdered plant materials (calendula, hibiscus) and their composite systems with A-300 nanosilicas having different bulk density has been studied by low-temperature 1H NMR spectroscopy method. The change in bulk density has been found to significantly affect the radius of inner cavities in fibrillar space of plant components. The composite systems based on wetting-drying compaction of nanosilica and plant powder have been showed to form a mix with high interaction energy of heterogeneous particles. This results in the effective retention of plant bioactive complex by composite, which enables the development of long-acting herbal drugs.
Keywords: calendula, composite systems, hibiscus, low-temperature 1H NMR spectroscopy, nanosilica, plant materials
1. Pogorelyy V.K. Patterns of adsorption of natural bioactive compounds on the surface of silica nanodispersed. Poverkhnost. 2009. 1(16): 322–349 (in Russian).
2. Chuiko A.A., Pogorelyy V.K., Barvinchenko V.N., Lipkovskaya N.A., Kovtyuhova N.I., Turov V.V. Chemical and Clinical verification of efficiency of drugs belonging to the phytosil family. Chemistry, physic and technology of surface. 1999. 3:3–9 (in Russian).
3. Lipkovska N.O., Barvinchenko V.N., Kosachevska N.F. Chemical-pharmaceutical research of phytocomposite based on herbs  and nanosilica. Poverkhnost. 2010. 2(17):321–329.
4.  Begma A.A., Begma L.A., Zemskov V.S., Uvarov V.Ju., Cimbaljuk R.S. Fitosil – novaja biologicheski aktivnaja dobavka prolongirovannogo dejstvija. 1-ja Rossijskaja nauchno-prakticheskaja konferencija “Aktual'nye problemy innovacij s netradicionnymi rastitel'nymi resursami i sozdanija funkcional'nyh produktov”. 18-19 June 2001, Moscow (in Russian).
5. Lipkovska N.O., Barvinchenko V.M., Turov V.V., Kartel M.T. Characterization of multicomponent herbal preparations by the integral indicators – antioxidant activity and total content of polyphenols. Dopovydy NAS Ukraine. 2014. No. 10: 123–130
6.  Turov V.V., Gun'ko V.M., Barvinchenko V.N., Rugal A.A., Turova A.A., Fedyanina T.V. Hydration of cellulose in the presence of quercetin and organic solvents. Chemistry, Physics and Technology of Surface. 2009. 15:169-180 (in Russian).
7. Shulga O.V., Kerchhoff J., Turov V.V. The influence of the dispersed oxides on the interface energy of the microcristalline cellulose in water suspension, mesoporous and microporous materials. Chemistry, Physics and Technology of Surface. 2001. 4-6: 267-274.
8. Gun'ko V.M., Turov V.V., Gorbik P.P. Water at the interface. Kiev: Naukova dumka, 2009 (in Russian).
9. Patent of Ukraine N 105151, Krupska T.V., Turov V.V., Barvinchenko V.M., Filatova K.O., Suvorova L.A., Kartel M.T. Method of nanosilica condensation (in Ukrainian).
10. Turov V.V., Gun'ko V.M. Clustered water and ways to use. Kiev: Naukova dumka, 2011 (in Ukrainian).
11.  Gun'ko V.M., Turov V.V. Nuclear Magnetic Resonance Studies of Interfacial Phenomena. New York: Taylor & Francis, 2013.
12. Chuiko A.A. (ed). Medical chemistry and clinical use of silica dioxide. Kiev: Naukova dumka, 2003 (in Russian).
13. Turov, V.V., Gun'ko, V.M., Turova, A.A., Morozova, L.,Voronin, E.F.  Interfacial behavior of concentrated HCl solution and water clustered at a surface of nanosilica in weakly polar solvents media. Colloids Surf. A: Physicochem. Eng. Aspects, 2011, 390: 48-55.
14. Alyoshyna L.A., Gurtova V.A., Meleh N.V. (ed) Structure and physico-chemical properties of cellulose and their nanocomposites, Petrozavodsk: PetrGU, 2014 (in Russian).