Mechanisms of Weak Magnetic Field Influence on Gene Expression: Basics of Physical Epigenetics

1Zaporozhan, VM, 1Ponomarenko, AI
1Odessa National Medical University, Odessa
Nauka innov. 2011, 7(6):50-69
Section: Scientific Basis of Innovation Activity
Language: Russian
According to the developed theory, proteins of the Cryptochrome family (CRY) are the primary magnetic field acceptor in the cell genome. These proteins are known as repressors of the major circadian transcriptional complex CLOCK/BMAL1. The mechanism described allows magnetic field to perform bioregulation functions on genome level. The magnetic field-mediated bioregulation isable to influence human health and may have epidemiological, evolutionary, climate-regulatory and ot her global consequences for biosphere.
Keywords: circadian rhythms, Cryptochrome, electromagnetic field, gene expression, NF-κB, radical pairs, transcription
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