Organization of Industrial Production of Flokalin — New Myotropic Spasmolytic and Cardioprotector

1Moybenko, OO, 1Strutynskyi, RB, 2Yagupolskii, LM, 3Mohort, MA, 4Shalamai, AS
1O.O. Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv
2Institute of Organic Chemistry, NAS of Ukraine, Kyiv
3SO Institute of Pharmacology and Toxicology, AMS of Ukraine, Kyiv
4EC "Borschagovsky Chemical-Pharmaceutical Plant", Kyiv
Nauka innov. 2009, 5(1):80-84
https://doi.org/10.15407/scin5.01.080
Section: Scientific and Technical Innovative Projects of National Academy of Sciences of Ukraine
Language: Ukrainian
Abstract: 
Technological scheme of synthesis of a new domestic cardioprotective drug — Flokalin have elaborated. Tablet — drug form of Flokalin was manufactured. It was shown that new Flokalin has expressed cardioprotective properties and limits heart infarct size by 34 % as compared to the control group. It was shown that one of the Flokalin cardioprotection mechanism at experimental acute ischemia-reperfusion can be increase of iNOS/cNOS proportion activity.
Keywords: cardioprotection, drug form, flokalin, ischemia/reperfusion, safety
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