The Results of the Study of Human Anomalous Thermal Fields Under Irradiation

1Glushchuk, NI, 1Gordiyenko, EYu., 1Fomenko, Yu.V, 1Shustakova, GV, 2Miroshnichenko, LG, 3Kolotilov, NN
1Verkin Institute for Low Temperature Physics and Engineering, NAS of Ukraine
2Kharkiv Regional Clinical Oncology Center
3Institute of Nuclear Medicine and Diagnostic Radiology of the NAMS of Ukraine
Nauka innov. 2017, 13(2):48-58
https://doi.org/10.15407/scin13.02.048
Section: Research and Engineering Innovative Projects of the National Academy of Sciences of Ukraine
Language: Russian
Abstract: 
The results of thermal imaging study of thermal fields on the skin surface of cancer patients treated with radiotherapy have been presented. Quantitative and statistical approach to the analysis of thermal images has been described. The results of thermal survey of patients before the start of irradiation have showed that thermal imaging diagnostics of the majority of internal tumors is limited or even impossible. However, the obtained correlation coefficients R = 0.76÷0.81 between the thermal parameters and the clinical side toxic reaction indicators, as well as the resulting «good quality» parameter of prognosis method have proved the possibility of using the thermal imaging method for monitoring and prediction of side toxic reactions of radiation therapy. The necessity of increasing the statistical power of the analyzed samples has been noted.
Keywords: radiotherapy, side toxic reactions, thermal imaging, tumor
References: 
1. Diakides N. A., Bronzino J.D. Medical Infrared Imaging. New York: CRC Press, 2007.
https://doi.org/10.1201/9781420008340
2. Cohen E., Ahmed O., Kocherginsky M., Shustakova G., Kistner-Griffin E., Salama J., Yefremenko V., Novosad V. Study of Functional Infrared Imaging for Early Detection of Mucositis in Locally Advanced Head and Neck Cancer Treated With Chemoradiotherapy. Oral Oncology. 2013, 49 (10): 1025-1031.
https://doi.org/10.1016/j.oraloncology.2013.07.009
3. Shustakova G.V., Fomenko Yu.V., Gordiyenko E.Yu., Glushchuk N.I., Vinnik Yu.A., Yefimova G.S., Miroshnichenko L.G., Lisanets M.P. Ispolzovanie termograficheskogo metoda dlya kontrolya i prognozirovaniya urovnya mukozita pri luchevoy terapii opuholey golovyi/shei (Application of infrared thermal imaging for monitoring and prediction of mucositis grade in the course of radiotherapy of head/neck tumors). Ukrainskiy radiologicheskiy zhurnal (Ukrainian Journal of Radiology). 2015. XXIII (3). 25-30 [in Russian].
4. Shustakova G.V., Glushchuk N.I., Gordiyenko E.Yu., Yefimova G.S., Miroshnichemko L.G., Kolotilov N.N., Fomenko Yu.V. IR Imaging study of metastatic lymph nodes and lymphomas during radiotherapy. Luchevaya diagnostika. Luchevaya terapiya. (Radiodiagnostics. Radiotherapy). 2015, 3: 41-46.
5. Shustakova G.V., Kolotilov N.N, Glushchuk N.I., Gordiyenko E.Yu., Miroshnichenko L.G., Fomenko Yu.V., Shustakova T.B. IR imaging: identification of regional metastasis. Luchevaya diagnostika. Luchevaya terapiya. (Radiodiagnostics. Radiotherapy). 2016, 3: 15-20.
6. Mabuchi K., Chinzei T., Fujimasa I., Haeno S., Motomura K., Abe Y., Yonezava T. Evaluating asymmetrical thermal distributions through image processing. IEEE Engineering in Medicine and Biology Magazine. 1998, 17 (4): 47-55.
https://doi.org/10.1109/MEMB.1998.687963
7. Gordienko E.Yu., Glushchuk N.I., Pushkar' Yu.Ya., Fomenko Yu.V., Shustakova G.V. A Multielement Thermal Imaging System Based on an Uncooled Bolometric Array. Instruments and Experimental Techniques. 2012, 55(4): 494-497.
https://doi.org/10.1134/S0020441212030050
8. Literature Review of Breast Thermography
http://www.medithermclinic.com/breast/BREAST%20THERMOGRAPHY%20-%20REVIEW...
9. Ivanitskii G.R., Deev A.A., Krest'eva I.B., Khizhnyak E.P., Khizhnyak L.N. Characteristics of Temperature Distributions around the Eyes. Doklady Biological Sciences (Reports of Biological Sciences). 2004, 398: 367-372.
https://doi.org/10.1023/B:DOBS.0000046658.90357.2d
10. Rumyantsev P.O., Saenko V.A., Rumyantseva U.V., Chekin S.Yu. Statisticheskie metody analiza v klinicheskoy praktike (Statistical analysis methods in clinical practice)
http://medstatistic.ru/articles/StatMethodsInClinics.pdf [in Russian].
11. Glants S. Mediko-biologicheskaya statistika [Biomedical Statistics]. Moskwa: Praktika, 1999. [in Russian].
12. Software packages VassarStats at http://vassarstats.net and at www.graphpad.com