Bone diseases are quite common among the Ukrainian population and occur in most children with leukemia. Therefore, the Corectin preparation has been developed on the basis of fundamental research conducted earlier at the Palladin Institute of Biochemistry of the NAS of Ukraine. Corectin has proved itself to be an effective remedy for the treatment of bone lesions of various genesis, including those occurring in hemoblastoses. The purpose of this research is to assess the prospects for application of Corectin and Glycivit C dietary supplements based on Corectin preparation and to introduce them into production. As a result, it has shown that these dietary supplements can be used as an additional source of glycine for functional normalization of nervous and immune systems. It increases bone density, cleanses the blood, decreases psycho-emotional tension, speeds up alcoholic detoxification, and, possibly, can be used for the treatment of bone and liver diseases and oncohematological pathologies. The obtained results of marketing research testify that bringing the developed supplements to market will be expedient. The trial batches of dietary supplements have been made with involvement of Nutrimed LTD (Ukraine). The specifications for production have been approved and listed in the national registry of specifications. The developed supplements have been endorsed by State Research Center for Food Hygiene of the Ministry of Health of Ukraine and the Marzeev Institute of Public Health of NAMS of Ukraine.

1. Povorzniuk V.V. Diseases of the musculoskeletal system in people of different ages (selected lectures, reviews, articles): in 3 v. V. 2. Kyiv: Express, 2009. 482 p.
2. Bebeshko V.G., Bruslova K.M., Tsvetkova N.M., Volodina T.T., Kopylova O.V., Belinhio T.O., Berezovskyi S.Ia., Petrunko M.P., Boiarskyi V.H., Polianska V.M., Pushkarova T.I., Mishchenko L.P. Preventive measures in children with acute leukemia exposed to ionizing radiation the accident. Evaluation of treatment and preventive measures to correct bone structure in children with acute leukemia, exposed to ionizing radiation due to the Chernobyl accident. Problemy radiatsiinoi medytsyny ta radiobiolohii: zbirnyk naukovykh prats. 2014. V. 19. P. 192-202.
3. Bebeshko V.G., Bruslova K.M., Volodina T.T., Tsvietkova N.M., Liashenko L.O., Pushkarova T.I., Voloshko V.I., Chernysh T.O., Trykhlib I.V. Determining the relationship between amino acid composition of the urine, and bone density in children with acute leukemia for the formation of the group risk hematologic pathology. Likuval’na sprava. 2014. No. 12. C. 34-40.
4. Gulyi M.F., Volodina T.T., Fedorchenko E.Ia., Pechenova T.N., Nazarevskaia N.N. Biosynthesis of rat skin collagen under amino acid imbalance. Ukraynskyi byokhymycheskyi zhurnal. 1978. V. 51, No. 4. P. 421-424.
5. Bruslova K. M. Report on clinical trial of the drug "Corectin" stage I. 2004. 34 p.
6. Safety (MSDS) data for glycine. The Physical and Theoretical Chemistry Laboratory Oxford University. 2005.
7. Yamadera W., Inagawa K., Chiba S., Bannai M., Takahashi M., Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 2007. V. 5, No. 2. P. 126-131.
https://doi.org/10.1111/j.1479-8425.2007.00262.x
8. Coyle J.T., Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology. 2004. V. 174, No. 1. P. 32-28.
https://doi.org/10.1007/s00213-003-1709-2
9. Diegelmann R. Collagen Metabolism. URL: http://www.medscape.com/viewarticle/423231 (Last accessed: October 1, 2001).
10. Englard S., Seifter S. The biochemical functions of ascorbic acid. Annu. Rev. Nutr. 1986. N 6. P. 365-406.
https://doi.org/10.1146/annurev.nu.06.070186.002053
11. Vrhovski B., Weiss A.S. Biochemistry of tropoelastin. European Journal of Biochemistry. 1998. V. 258, N 1. P. 118.
https://doi.org/10.1046/j.1432-1327.1998.2580001.x
12. Kielty C.M., Sherratt M.J., Shuttleworth C.A. Elastic fibres. Journal of Cell Science. 2002. V. 115, Pt. 14. P. 2817-2828. 
13. Bannai S., Tateishi N. Role of membrane transport in metabolism and function of glutathione in mammals. The Journal of Membrane Biology. 1986. V. 89, No. 1. P. 18.
https://doi.org/10.1007/BF01870891
14. Levine M., Rumsey S.C., Wang Y., Park J.B., Daruwala R. Vitamin C. Stipanuk M.H. Biochemical and physiological aspects of human nutrition. Philadelphia: W.B. Saunders, 2000. P. 541-567.
15. Deruelle F., Baron B. Vitamin C: is supplementation necessary for optimal health? J. Altern. Complement. Med. 2008. V. 14, No. 10. P. 1291-1298.
https://doi.org/10.1089/acm.2008.0165
16. Bebeshko V.G., Bruslova K.M., Tsvetkova N.M., Volodina T.T., Pushkareva T.I. Correction of the organic and mineral matrix of bone tissue in children with acute leukemia which are subjected to adverse environmental factors. Informatsiinyi lyst. 2014. 3 p.
17. Scientific materials of the XVII Congress of orthopedists-traumatologists of Ukraine (October 5-7, 2016, Kiev). K.: "Ukrainian Association of Orthopedics-Traumatologists" and "Institute of Traumatology and Orthopedics of NAMS of Ukraine", 2016. 265 p.
18. Fedorenko Z.P., Hulak L.O., Mykhailovych Yu.I., Horokh Ye.L., Ryzhov A.Iu., Sumkina O.V., Kutsenko L.B. Bulletin of National cancer registry of Ukraine N 18. Cancer in Ukraine in 2015-2016. Incidence, mortality, activities of oncological service. Kyiv: Natsionalnyi instytut raku. (National Cancer Institute). 2017. 123 p.
19. Annual report on the health status of the population, sanitary and epidemiological situation and activities results of the health care system of Ukraine. 2015. By ed. Shafranskyi V.V. Kyiv: MOZ Ukrainy, DU «UISD MOZ Ukrainy», 2016. 452 p. 
20. Hahn R.G. Dose-dependent half-life of glycine. Urological Research. 1993. V. 21, No. 4. P. 289-291.
https://doi.org/10.1007/BF00307714