Nauka innov. 2015, 11(2):46-52

I.M. Todor1, N.Yu. Lukianova1, N.K. Rodionova1, O.O. Shevchuk2, V.G. Nikolaev1, V.F. Chekhun1
1 R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine, Kyiv
2 I.Ya. Horbachevsky Ternopil State Medical University, MC of Ukraine, Ternopil


Myeloprotective Action of Combined Application of Ukrainian Recombinant Granulocyte Colony Stimulating Factor (r-GCSF) and Enterosorbent С2 in Rats with Malignant Guerin Carcinoma

Section: Scientific and Technical Innovative Projects of National Academy of Sciences of Ukraine
Language: Ukrainian
Abstract: The aim of the study is to analyze myeloprotective effect of novel enterosorbents alone and in combination with two recombinant granulocyte colony stimulating factors: Neupogen (Switzerland) and r- GCSF (Ukraine). It is proven that Ukrainian version of recombinant granulocyte colony stimulating factor r-GCSF does not concede officinal drug Neupogen (Switzerland) by its experimental therapeutic action and combined use with enterosorbent C2 significantly increases myeloprotective effect of both GCSF versions.
Key words: tumor, myelosupression, granulocyte colony stimulating factor, enterosorbtion.

1. Milijašević B., Stefanović D., Lalić-Popović M. et al. Acute toxic effects of single dose dacarbazine: hematological and histological changes in an animal model. Biotech. Histochem., 2014, 5, pp. 1—8 [in English].
2. Wensing K.U., Ciarimboli G. Saving ears and kidneys from cisplatin. Anticancer Res., 2013, 33, N 10, pp. 4183—4188 [in English].
3. Qi S., Wu D. Bone marrow-derived mesenchymal stem cells protect against cisplatin-induced acute kidney injury in rats by inhibiting cell apoptosis. Int. J. Mol. Med., 2013, 32, N 6, pp. 1262—1272 [in English].
4. Sardi A., Jimenez W., Nieroda C. et al. Melphalan: a promising agent in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann. Surg. Oncol., 2014, 21, N 3, pp. 908—914 [in English].
5. Manko J., Walter-Croneck A., Jawniak D. et al. A clinical comparison of the efficacy and safety of biosimilar GCSF and originator G-CSF in haematopoietic stem cell mobilization. Pharmacol. Rep., 2014, 66, N 2, pp. 239—242 [in English].
6. Quirion E. Filgrastim and pegfilgrastim use in patients with neutropenia. Clin. J. Oncol. Nurs., 2009, 13, N 3, pp. 324—328 [in English].
7. Shevchuk O.O., Posokhova E.A., Sakhno L.A. et al. Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity. Exp. Oncol., 2012, 34, N 4, pp. 314—322 [in English].
8. Sarnatskaya V.V., Sidorenko A.S., Klymchuk D.A. et al. Optimization of physico-chemical properties of carbon enterosorbents and evaluation of their sorption activity for use in the treatment of paraneoplastic syndrome and other endogenous intoxications in cancer patients. Exp. Oncol., 2013, 35, N 2, pp. 83—88 [in English].
9. Sakhno L.A., Yurchenko O.V., Maslenniy V.N. et al. Enterosorption as a method to decrease the systemic toxicity of cisplatin. Exp. Oncol., 2013, 35, N 1, pp. 45—52 [in English].
10. Shevchuk O.O., Posokhova K.A., Sidorenko A.S. et el. The influence of enterosorption on some haematological and biochemical indices of the normal rats after single injection of melphalan. Exp. Oncol., 2014, 36, N 2, pp. 1—7 [in English].