Improvement of Production System of Domestic Diagnostic Preparation «Lantavist»
| Title | Improvement of Production System of Domestic Diagnostic Preparation «Lantavist» |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Korovin, Yu.V, Rusakova, NV, Smola, SS, Grigorasheva, IM |
| Short Title | Nauka innov. |
| DOI | 10.15407/scin6.06.031 |
| Volume | 6 |
| Issue | 6 |
| Section | Scientific and Technical Innovative Projects of National Academy of Sciences of Ukraine |
| Pagination | 31-37 |
| Language | Ukrainian |
| Abstract | With the help of improved technique the basic chemical component of gadolinium diethylenetriaminepentaacetate preparation substance is obtained. The additional methods (spectrophotometry and luminescent) of control of substance components’ and medicinal form’s (indicated complex with D(-)-N-methylglucamine) quality are developed. The technological line of preparation overflow resulting in diminishing of its production losses is improved.
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| Keywords | compounds of gadolinium, diagnostic means, identification, magnetic-contrast substances |
| References | 1. Lauterbur P.C., Medonca-Dias M.H., Rudin A.M. Augmentation of tissue water protein spin-lattice relaxation rates by in vivo addition of paramegnetic ions. Front. Biol. Engin. 1978. V. 1. P. 752-759.
2. Babij Ja.S., Demin V.T. Sostojanie i perspektivy razvitija MRT v Ukraine. Med. vesti. 1999. No 1: 36-38 [in Russian]. 3. Weinmann H.-J., Brasch R.C., Press W.R., Wesbey G.E. Characteristics of gadolinium-DTPA complex: a potencial NMR contrast agent. Amer. J. Roengenol. 1984. V. 142. P. 619-624. https://doi.org/10.2214/ajr.142.3.619 4. Carr D.H., Brown G., Bydder G.M., et all. Intravenous chelated gadolinium as a contrast agent in NMR imaging of cerebral tumors. Lancet. 1984. V. 3. P. 484-486. https://doi.org/10.1016/S0140-6736(84)92852-6 5. Sergeev P.V., Bolotova E.N., Korovin Ju.V. i dr. Azaciklicheskij piridinsoderzhashhij kompleks gadoli nija kak perspektivnyj paramagnitnyj kont rastnyj agent v magnitnorezonansnoj tomografii. Him.-farm. zhurn. 1996. No 3: 21-22 [in Russian]. 6. Patent Ukrai'ny N 6177, A61K 49/00. Sposib oderzhannja zasobu dlja magnitno-rezonansnoi' tomografii'. Ju.V. Korovin, N.V. Rusakova, S.M. Chesnov, V.V. Gorashhenko [in Ukrainian]. 7. Korovin Yu., Popkov Yu., Rusakova N. Luminescence of gadolinium complexes with 1,4,7,10-tetraaza-2,6-py ridinophane[12]-1,4,7-triacetic acid. Mendeleev Commun. 1996. V. 1. P. 7-8. https://doi.org/10.1070/MC1996v006n01ABEH000553 8. Laniado M., Weinmann H.-J., Schurner W., et all. First use of Gd-DTPA. Dimeglumine in man. Physiol. Chem. and Phys. and Med. NMR. 1984. V. 16. P. 157-165. 9. Weinreb J.C., Devis S.D., Berkmen Y.M. Pulmonary artery sarcoma: evalution using Gd-DTPA. J. Comput. As sist. Tomography. 1990. V. 14. P. 647-649. https://doi.org/10.1097/00004728-199007000-00025 10. Brechbiel MW., Gansow O.A., Atcher R.W., et all. Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies. Inorg. Chem. 1986. V. 25. P. 2772-2781. https://doi.org/10.1021/ic00236a024 11. Korovin Yu., Popkov Yu., Rusakova N. Luminescence of ga dolinium complexes with 1,4,7,10-tetraaza-2,6-py ridinophane[12]-1,4,7-triacetic acid. Mendeleev Commun. 1996. V. 1. P. 7-8. https://doi.org/10.1070/MC1996v006n01ABEH000553 |