The effects of new generation analgetic drug «Gabagamma » for neuropathic disorders treatment in diabetes was studied. «Gabagmma» specific selectivity was shown. Conclusions on the possibility of «Gabagamma» application as self-sufficient pain reliever in pain syndrome treatment were made.

1. Jen-Kun Cheng, Lih-Chu Chio. Mechanisms of the Antinociceptive Action of Gabapentin. J Pharmacol Sci. 2006. No 10. P. 471-486.
2. Shimoyama N., Shimoyama M., Davis A.M. Spinal ga bapen tin is antinociceptive in the rat formalin test. Neuros ci. Lett. 1997. No 1(222). P. 65-67.
3. Romanenko S.V., Kostjuk P.G., Kostjuk E.P. Vplyv gabapentinu na kal'cijevi tranzijenty v nejronah dorsal'nokorincevyh ganglii'v shhuriv. Nejrofyzyologyja. 2008, no 4(40): 281-287 [in Ukrainian].
4. Ganong V.F. Fiziologija ljudyny. L'viv: BaK, 2002 [in Ukrainian].
5. Guyton A., Hall J. Medical physiology. Elsever. Printed in China, 2006. P. 1116.
6. Scroggs R.S., Fox A.P. Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size. The J. Physiology. 1992. No 1(442). P. 639-658.
7. Sutton K.G., Martin D.J., Pinnock R.D. Gabapentin in hibits high-threshold calcium channel currents in cultured rat dorsalroot ganglion neurones. British J. Pharm. 2002. No 1(135). P. 257-265.
8. Marais E., Klugbauer N., Hofmann F. Calcium channel α2δ subunits-structure and gabapentin binding. Mol Phar macol. 2001. No 5(59). P. 1243-1248.
9. Luo Z. D., Chaplan S. R., Yaksh T. N. Upregulation of dor sal root ganglion α2δ calcium channel subunit and its cor relation with allodynia in spinal nerve-injured rats. J. Neurosci. 2001. No 6(21). P. 1868-1875.
10. Kostjuk P.G., Kostjuk O.P., Luk’janec' O.O. Iony kal'ciju u funkcii' mozku - vid fiziologii' do patologii'. Kyiv: Nauk. dumka, 2005 [in Ukrainian].
11. Hong S., Wiley J.W. Early painful diabetic neuropathy is as so ciated with differential changes in expression and fun ction of vanilloid receptor 1. J. Biol. Chem. 2005. No 1 (280). P. 618-627.
12. Hong S., Agresta L., Guo C. The TRPV1 is associated with peripheral stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy. J. Neurochem. 2008. No 4(105). P. 1212-1222.