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Organization of Industrial Production of Flokalin — New Myotropic Spasmolytic and Cardioprotector

TitleOrganization of Industrial Production of Flokalin — New Myotropic Spasmolytic and Cardioprotector
Publication TypeJournal Article
Year of Publication2009
AuthorsMoybenko, OO, Strutynskyi, RB, Yagupolskii, LM, Mohort, MA, Shalamai, AS
Short TitleNauka innov.
DOI10.15407/scin5.01.080
Volume5
Issue1
SectionScientific and Technical Innovative Projects of National Academy of Sciences of Ukraine
Pagination80-84
LanguageUkrainian
Abstract
Technological scheme of synthesis of a new domestic cardioprotective drug — Flokalin have elaborated. Tablet — drug form of Flokalin was manufactured. It was shown that new Flokalin has expressed cardioprotective properties and limits heart infarct size by 34 % as compared to the control group. It was shown that one of the Flokalin cardioprotection mechanism at experimental acute ischemia-reperfusion can be increase of iNOS/cNOS proportion activity.
Keywordscardioprotection, drug form, flokalin, ischemia/reperfusion, safety
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