Organization of Industrial Production of Flokalin — New Myotropic Spasmolytic and Cardioprotector
Title | Organization of Industrial Production of Flokalin — New Myotropic Spasmolytic and Cardioprotector |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Moybenko, OO, Strutynskyi, RB, Yagupolskii, LM, Mohort, MA, Shalamai, AS |
Short Title | Nauka innov. |
DOI | 10.15407/scin5.01.080 |
Volume | 5 |
Issue | 1 |
Section | Scientific and Technical Innovative Projects of National Academy of Sciences of Ukraine |
Pagination | 80-84 |
Language | Ukrainian |
Abstract | Technological scheme of synthesis of a new domestic cardioprotective drug — Flokalin have elaborated. Tablet — drug form of Flokalin was manufactured. It was shown that new Flokalin has expressed cardioprotective properties and limits heart infarct size by 34 % as compared to the control group. It was shown that one of the Flokalin cardioprotection mechanism at experimental acute ischemia-reperfusion can be increase of iNOS/cNOS proportion activity.
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Keywords | cardioprotection, drug form, flokalin, ischemia/reperfusion, safety |
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