Development of Immunochemical Test Systems for Anti-Diphtheria Immunity Control in Population of People

TitleDevelopment of Immunochemical Test Systems for Anti-Diphtheria Immunity Control in Population of People
Publication TypeJournal Article
Year of Publication2008
AuthorsKaberniuk, АА, Oliinyk, OS, Redchuk, ТА, Romanyuk, SІ, Kolybo, DV, Ievtushenko, VV, Golovach, OV, Kramarev, SO, Komisarenko, SV
Short TitleNauka innov.
DOI10.15407/scin4.03.022
Volume4
Issue3
SectionScientific and Technical Innovative Projects of National Academy of Sciences of Ukraine
Pagination22-31
LanguageUkrainian
Abstract
Diagnostic test-systems for rapid and effective assessment of antidiphtheria immunity are developed. The prototypes of immunochemical test-systems based on enzymelinked immunosorbent and immunochromatographic assays for detection of antibodies to diphtheria toxin subunits A and B in human serum are presented. It was suggested to use recombinant subunits of diphtheria toxin as antigens that allowed to define the specificity of anti-diphtheria antibodies in human sera.
Keywordsdiphtheria, diphtheria toxin's recombinant subunits, elisa, immunochromatography, protective immunity evaluation
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