Development of Immunochemical Test Systems for Anti-Diphtheria Immunity Control in Population of People
Title | Development of Immunochemical Test Systems for Anti-Diphtheria Immunity Control in Population of People |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Kaberniuk, АА, Oliinyk, OS, Redchuk, ТА, Romanyuk, SІ, Kolybo, DV, Ievtushenko, VV, Golovach, OV, Kramarev, SO, Komisarenko, SV |
Short Title | Nauka innov. |
DOI | 10.15407/scin4.03.022 |
Volume | 4 |
Issue | 3 |
Section | Scientific and Technical Innovative Projects of National Academy of Sciences of Ukraine |
Pagination | 22-31 |
Language | Ukrainian |
Abstract | Diagnostic test-systems for rapid and effective assessment of antidiphtheria immunity are developed. The prototypes of immunochemical test-systems based on enzymelinked immunosorbent and immunochromatographic assays for detection of antibodies to diphtheria toxin subunits A and B in human serum are presented. It was suggested to use recombinant subunits of diphtheria toxin as antigens that allowed to define the specificity of anti-diphtheria antibodies in human sera.
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Keywords | diphtheria, diphtheria toxin's recombinant subunits, elisa, immunochromatography, protective immunity evaluation |
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