Development of New Openers of ATP-Sensitive Potassium Channels of the Cell Membranes

TitleDevelopment of New Openers of ATP-Sensitive Potassium Channels of the Cell Membranes
Publication TypeJournal Article
Year of Publication2016
AuthorsStrutynskyi, RB, Strutynska, NA, Maximyuk, OP, Platonov, MO, Boyko, OM, Vasylchenko, OV, Fedyanovich, IM, Dosenko, VYe., Krishtal, OO
Short TitleNauka innov.
SectionResearch and Engineering Innovative Projects of the National Academy of Sciences of Ukraine
Two innovative libraries (413 cyclosulfamides and 709 orthopyridine sulfamides) of potential new openers of ATP-sensitive potassium channels of cell membranes were developed. It is shown experimentally that at least ten new original compounds have properties of pharmacological openers of the channels. Seven compounds, namely Z851154982, Z56762024, Z1269122570, Z31153162, Z45679561, Z756371174 and Z649723638, open channels of both types — sarcoplasmic as well as mitochondrial membranes: Simultaneously, Z734043408 compound is a potent activator of aforementioned channels of sarcolemmal membrane only. Z31197374 and Z666664306 compounds show the affinity onlyto КATP-channels of mitochondrial type. The results of the work can be used by pharmaceutical companies and scientific research institutes.
Keywordsglibenclamide, KATP-channels, mitochondria, new openers, vasodilation effects