Nauka innov. 2015, 11(1):72-77

I.S. Chekman
O.O. Bogomolets National Medical University, Kyiv, Ukraine


Pharmacological Properties of Nanometals (Silver, Copper, Iron)

Section: Celebrating the 10th Anniversary of the Journal
Language: Ukrainian
Abstract: The article summarizes the results of studies on the pharmacological, toxicological and specific properties of nanometals (silver, iron, copper). It is established that nanoparticles of silver, copper, iron exhibit antimicrobial action. Acute toxicity of nanometals depends on their nature, administration route and animal sex. Effects on heart activity and hemodynamic status as well as erythrocyte osmotic fragility have dose-dependent nature.
Key words: nanoparticles, nanosilver, nanocopper, nanoiron, properties.

1. Volkov, S.V., Kovalchuk S.P., Genko V.M., and Reshetniak O.V. (2008). Nanochemistry. Nanosystems. Nanomaterials. Kyiv: Naukova Dumka (in Ukrainian).
2. Chekman, I.S., Ulberg Z.R., Malanchuk V.O., et al. (2012). Nanoscience. Nanobiology. Nanopharmacology. Kyiv: Polygraph Plus (in Ukrainian).
3. Nanomaterials and Nanocomposites in Medical Science, Biology, and Ecology. (2011). In: Shpak, A.P. and Chekhun, V.F. (Eds.). Kyiv: Naukova Dumka (in Russian).
4. Chekman, I.S. (2011). Nanopharmacology. Kyiv: Zadruha (in Ukrainian).
5. Gang, L., Xiaohong, L., and Zhijun, Z.: Preparation Methods of Copper Nanomaterials. Prog. Chem., 23, 1644–1656 (2011).
6. Giannossa, L.C., Longano, D., Ditaranto, N., Nitti, M.A., Paladini, F., Pollini, M., Rai, M., Sannino, A., Valentini, A., and Cioffi, N.: Metal Nanoantimicrobials for Textile Applications. Nanotechnol. Rev., 2(3), 307–331 (2013).
7. Chekman, I.S., Ulberg, Z.R., Gorchakova, N.O. et al.: The Prospects of Medical Application of Metal-Based Nanoparticles and Nanomaterials. Lik. Sprava, 1–2, 3–21 (2011).
8. Balarajan, Y., Ramakrishnan, U., Ozaltin, E., et al.: Anaemia in Low-Income and Middle-Income Countries. Lancet., 378, 9809, 2123–2135 (2011).
9. Worldwide Prevalence of Anaemia 1993–2005: WHO Global Database on Anaemia. (2008). In: Benoist, B. de McLean, E., Egli, I. and Cogswell, M. (Eds.).
10. Iron Deficiency Anemia. Assessment, Prevention, and Con trol. A Guide for Programme Managers. (2001). Geneva: WHO.
11. Nissenson, A.R., Goodnough, L.T., and Dubois, R.W.: Anemia: Not Just an Innocent Bystander? Arch. Intern. Med., 163, 12, 1400–1404 (2003).
12. Simonov, P.V.: Impact of Colloid Solution of Copper Nanoparticles on Heart Activity and Hemodynamics of Laboratory Rabbits. Lik. Sprava, 5, 110–115 (2013) (in Ukrainian).
13. Hong, H.A., Khaneja, R.; Tam, N. et al. Research in Microbiology, 160, 2, 134 – 43 (2009).
14. Banerjee, M., Mallick, S., Paul, A. et al.: Heightened Reactive Oxygen Species Generation in the Antimicrobial Activity of a Three Component Iodinated Chitosan-Si lver Nanoparticle Composite. Langmuir, 26, 8, 5901 – 5908 (2010).