1Krysiuk, IP, 1Gudkova, OO, 1Shandrenko, SG
1Palladin Institute of Biochemistry of the NAS of Ukraine
Nauka innov. 2018, 14(5):37-42
https://doi.org/10.15407/scin14.05.037
Section: Scientific Basis of Innovation Activity
Language: Ukrainian
Abstract: 
Introduction. Diabetes mellitus and gastrointestinal tract pathology are among the most common pathology of modern society. In Ukraine, the number of patients with all types of diabetes increases, with gastrointestinal tract diseases caused by Helicobacter pylori showing intensive upward dynamics because of transmission in domestic conditions. 
Problems. Therefore, two dietary supplements for the prevention and mitigation of diabetes mellitus and stomach helicobacteriosis have been developed on the basis of fundamental research conducted in the Palladin Institute of Biochemistry of the NAS of Ukraine.
Purpose. To evaluate the effectiveness of these dietary supplements.
Materials and Methods. The effectiveness of developed nutritional supplements has been confirmed by in vivo experiments. The degree of H. рylori infection ingress has been determined by non-invasive direct urease test using Helicotester device.
Results. The results have shown a high efficacy of the developed dietary supplements. Thus, the dietary supplement for diabetes reduces the content of toxic components, such as total amount of aldehydes, carbonyl groups and postsynthetic modification of proteins, which can suppress development of diabetes complications. The dietary supplement for helicobacteriosis has been proved to enable reducing the degree of H. pylori infection ingress in stomach, which can effectively prevent the development of gastrointestinal tract diseases.
Conclusions. The developed dietary supplements contain cheap and stable long-storable components, enable to effectively reduce the content of toxic components in the patients with diabetes and manifestations of certain gastrointestinal tract diseases, to improve the functioning of the body, and to maintain its working capacity and health. The authors are looking for investors to application of these dietary supplements to production.
Keywords: diabetes, dietary supplements, glycine, helicobacteriosis, lysine, N-acetylcysteine, silver nitrate, urea